2009) all postulated that an upright structure of the sort illustrated in Figure 1C could exist as well as the bent structure. The structural studies of intact ectodomains ( Xiong et al. 2005).īecause of observed flexibility in studies by electron microscopy (EM) and the existence of conformationally sensitive antibody recognition sites ( Humphries 2004), there is a general acceptance that conformations other than the bent one are possible and are functionally relevant (see below). 1995a) and β2-leg fragments ( Beglova et al. 2009) ( B) structure of αxβ2 using same color code as A (drawn with PyMOL using PDB coordinates 3K6S) ( C) cartoon representation of bent and upright conformations showing approximate dimensions.Ĭurrent knowledge of ectodomains has also been enhanced by structures of various integrin fragments including isolated α-I domains ( Lee et al. ( A) Domain structure of αxβ2 ( Xie et al.
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